مرکزی صفحہ Regulatory Peptides The effect of guar supplementation on gastrin, motilin and GIP secretion following a high protein...

The effect of guar supplementation on gastrin, motilin and GIP secretion following a high protein meal

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جلد:
3
سال:
1982
زبان:
english
DOI:
10.1016/0167-0115(82)90036-2
فائل:
PDF, 68 KB
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THE EFFECT OF GUAR SUPPLEMENTATION ON GASTRIN, MOTILIN AND GIP
SECRETION FOLLOWING A HIGH PROTEIN MEAL
L. Morgan, J. Tredger, 3. Wright, P. Kwasowski and V. Marks, Division o f Clinical
Biochemistry, Department of Biochemistry, University of Surrey, Guildford, U.K.
Addition of the unabsorbable carbohydrate guar gum to a meal has been shown to delay
gastric emptying and increase mouth-to-caecum transit time. The following study was
undertaken to ascertain whether these effects were associated with altered patterns of
GI hormone secretion. A f t e r a 12 h fast, 6 healthy non-obese volunteers were given a
meal of 150 g lean minced beef, providing 50 g protein and 7 g fat, either with or
without 5 g guar, incorporated into the meat.
1.5 g paracetamol was consumed
simultaneously on each occasion with 300 ml water, as an index of gastric emptying.
Blood was collected at intervals for 120 rain following the meal. Plasma paracetamol
levels were unaffected by addition of guar to the meal. Postprandial gastrin secretion
was significantly enhanced by the addition of guar. (Area under plasma gastrin curve
0-120 rain increased by 61 + 14%, p <0.005). Plasma m o t i l i n levels rose, but without
significant difference between control and guar meals (basal levels 108 _+ 18 ng/l; peak
levels for control and guar meals 155 + 37 ng/ml and 140 + 22 ng/ml respectively).
Plasma GIP levels were significantly diminished by addition of guar. (Peak plasma GIP
954 + 173 ng/l vs. 599 + 87 ng/l, p <0.05; area under curve 0-120 rain decreased by
27 _+-4%, p <0.05). The-enhancement of gastrin secretion by guar was apparently not
caused by differences in rates of gastric emptying, as estimated by paracetamol
levels.
GIP can stimulate gastric somatostatin release.
The increased gastrin
secretion could, therefore, be due to diminished post-prandial GIP secretion following
guar.
Alternatively, the augmented gastrin secretion may have been due to a
reduction in the negative feedback e f f e c t of gastric acid resulting from t; he buffering
capacity of guar.

EFFECT OF SOMATOSTATIN ON INTESTINAL FUNCTION.
A. Mitchell, J. Collin. (Nuffleld Department of Surgery, Oxford.)
In 3 dogs a segment of jejunum was isolated with proximal and distal stomata
on the abdominal
wall.
Electrodes were sutured to the serosal surface of
the segment.
The dogs were
fed before
each
experiment
a n d a solution
containing
90 mmol/L NaCl and 100 mmol/L glucose was infused at 2.9 mls/min
into the proximal stoma.
Effluent was collected from the distal stoma for 3
hours.
During the second hour somatostatin 2.5 ~gm/Kg./h. was continuously
infused
intravenously.
Effluent volumes were measured and their sodium and
glucose concentrations estimated.
Electrical recordings were made from the
jejunum throughout
the experiment.
Six experiments were performed on each
dog.
Compared with the control period somatostatin
produced
an immediate
fall
in volume output (5.5 ~ 0.33 to 2.]27 ~ 0.91;mean Z s.e.m, mls/5 mins)
[ p<O.O01 ].
Total output of glucose and sodium
were
also significantly
reduced$
Effluent glucose concentration rose (80 19 - 1 24 to 90 89 - 1.76
;mean
s.e.m,
mmol/L) ~ p<O.O01 ] and sodlum concentratlon fell (99.58 1.11 to 93.5 Z 1.01 ;mean - s.e.m, mEq/L) [ p<O.OO1 ].
Mean
transit
time
was
prolonged (7.4
to
15.3 mins) [ p<0.O01 ].
Fast wave +electrical
activity was significantly reduced (28 Z 1.4 to 1 1 Z 3.4
;mean - s.e.m./5
mins) [ p<O.O1 ] but slow wave
activity
was unaffected by somatostatin.
Somatostatin produces an apparent
increase
in intestinal
absorption
of
water, glucose and sodium;
reduces intestinal fast wave electrical activity
and slows transit.
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